Hyaluronidase
Structure: Six Hyal sequences occur in the human genome,
constituting a newly recognized family of enzymes.
Reactions:
“By catalyzing the hydrolysis of hyaluronan, a constituent of the extracellular matrix (ECM), hyaluronidase lowers the viscosity of hyaluronan, thereby increasing tissue permeability. It is, therefore, used in medicine in conjunction with
other drugs to speed their dispersion and delivery. Common applications are
opthalmic surgery, in combination with local anesthetics.” “They have similar
catalytic mechanisms that contrast markedly with the bacterial Hyals.” So the enzyme helps your body absorb medicines that are injected to
your skin.
Rates: “It also increases the absorption rate of parenteral fluids given by hypodermoclysis, and is an adjunct in subcutaneous urography for improving resorption of radiopaque agents. Hyaluronidase is also used for extravasation of hyperosmolar
solutions.”
Molecular
weight:
53870.9
g/mol
REFERENCES
You were asked to give information regarding the reaction rates for the catalyzed vs. uncatalyzed reaction...I don't see this!
ReplyDeleteWhere is the reaction scheme as well?
Hi Kelsey,
ReplyDeleteThe question I have for you is, what is the silver concentration in a solution prepared by mixing 500mL of .500M silver nitrate with 400mL of .600M sodium chromate? Given that the ksp of silver chromate 1.2x10^-12
2Ag+(aq)+CO3^2- (aq)----> Ag2CO3 (s)
Deletemol Ag+ .500 mol Ag+ X 500 mL X 1L = .25 mol Ag+
____________ ____
L 1000
mol CO3^2- .600 mol CO3^2- X 400 mL X 1L = .24 molCO3^2-
_______________ ____
L 1000
Used ICE------
2Ag+(aq)+CO3^2- (aq)----> Ag2CO3 (s)
.25 .24
-.25 -(.25/2)
_________________
0 mol .115 mol
[CO3^2-]= .115 mol CO3^2-
_________________ = .127M CO3^2-
(500+400) mL X 1L/1000
2Ag+ + CO3^2-
0M .127M
+2x +x
_____________
2xM (.127 + x) M Ksp = 1.2 x 10^-12
1.2 x 10^-12 = (2x)^2 (.127 + x)
(1.2 x 10^-12)^.5
__________________
.127M
FINAL ANSWER = 8.6 x 10^-6
Chromate ion is a dianion, CrO4_2-; not CO3_2-; which is carbonate!
DeleteYour response should have probably been worked out on paper and uploaded as an image on YOUR blog as a NEW entry.
I would suggest you go back and revisit this one ASAP!
Ag+ concentration?
DeleteIs this a copied Sapling Q?