Hyaluronidase
Structure: Six Hyal sequences occur in the human genome,
constituting a newly recognized family of enzymes.
Reactions:
“By catalyzing the hydrolysis of hyaluronan, a constituent of the extracellular matrix (ECM), hyaluronidase lowers the viscosity of hyaluronan, thereby increasing tissue permeability. It is, therefore, used in medicine in conjunction with
other drugs to speed their dispersion and delivery. Common applications are
opthalmic surgery, in combination with local anesthetics.” “They have similar
catalytic mechanisms that contrast markedly with the bacterial Hyals.” So the enzyme helps your body absorb medicines that are injected to
your skin.
Rates: “It also increases the absorption rate of parenteral fluids given by hypodermoclysis, and is an adjunct in subcutaneous urography for improving resorption of radiopaque agents. Hyaluronidase is also used for extravasation of hyperosmolar
solutions.”
Molecular
weight:
53870.9
g/mol
REFERENCES
